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Section: 9.10.020, 9.10.260 Bans: pit bulls
Cathlamet Section: 6.10.020 Bans: pit bulls
Coulee Dam Section: 6.10.010 Pit bulls declared "potentially dangerous"
Enumclaw Section: 7.08 Bans: pit bulls
Everett Section: 6.08.010 Pit bulls declared "potentially dangerous" | Historic 1987 legal notes
Everson Section: 6.08.020 Restricts: pit bulls
Grandview Section: 6.06.010 Pit bulls declared "dangerous"
Harrah News article Restricts: pit bulls
Harvey

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Health care: We have to do better for Iowans


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Is the era of hugging over? Some people sure hope so
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Who would have thought that hugging could trigger so much ire? After all, America today is a nation of huggers. But now we have #MeToo. And love turns out that not everyone needs a hug.
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Presidents' Day or President's Day? Depends on whom you ask
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When love comes to punctuating the February holiday, we're a divided nation.
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Claims:
1. An integrated composite hemostat in the form of nonwoven fabric, wherein (i) at least one web of a first polymer selected from the group consisting of a biodegradable polymer, oxidized regenerated cellulose and an alkali metal salt-neutralized product of oxidized regenerated cellulose and (ii) at least one web of a second polymer selected from the group consisting of oxidized regenerated cellulose and an alkali metal salt-neutralized product thereof are integrated by overlapping, needle punching and compression,
wherein the polymer webs of (i) and (ii) have different hemostatic effect or antiadhesive effect each other.

2. The integrated composite hemostat according to Claim 1, wherein (iii) at least one web of a third polymer selected from the group consisting of oxidized regenerated cellulose and an alkali metal salt-neutralized product thereof is further integrated,
wherein the polymer webs of (i), (ii) and (iii) have different hemostatic effect or antiadhesive effect one another.

3. The integrated composite hemostat according to Claim 1, wherein
at least one web of a biodegradable polymer and at least one web of oxidized regenerated cellulose;
at least one web of a biodegradable polymer and at least one web of an alkali metal salt-neutralized product of oxidized regenerated cellulose;
at least one web of oxidized regenerated cellulose and at least one web of an alkali metal salt-neutralized product thereof;
two or more oxidized regenerated celluloses or alkali metal salt-neutralized products thereof, each having different oxidation degrees; or
at least one web of a biodegradable polymer, at least one web of oxidized regenerated cellulose and at least one web of an alkali metal salt-neutralized product of oxidized regenerated cellulose are integrated.

4. The integrated composite hemostat according to Claim 1, wherein the biodegradable polymer is selected from the group consisting of lactic acid-glycolic acid copolymer (PGLA), polyglycolic acid (PGA), poly(1,4-dioxan-2-one) (PDO), polycaprolactone (PCL), polyglycolic acid-polycaprolactone copolymer (PGA-PCL) and mixtures thereof.

5. The integrated composite hemostat according to Claim 1, wherein the biodegradable polymer is gamma-irradiated.

6. The integrated composite hemostat according to Claim 1, wherein the polymer web is a fibrillar web prepared by carding of fabric or knit of polymer.

7. The integrated composite hemostat according to Claim 1, wherein the web of a biodegradable polymer, the web of an alkali metal salt-neutralized product of oxidized regenerated cellulose, or the web of a biodegradable polymer and the web of an alkali metal salt-neutralized product of oxidized regenerated cellulose contain a hemostasis-promoting agent.

8. The integrated composite hemostat according to Claim 7, wherein the hemostasis-promoting agent is selected from the group consisting of thrombin, fibrinogen, thromboplastin, casein kinase II, tissue factor, carboxymethyl cellulose, collagen, gelatin and combinations thereof.

9. The integrated composite hemostat according to Claim 1, wherein the alkali metal salt-neutralized product of oxidized regenerated cellulose is sodium salt of the oxidized regenerated cellulose.

10. The integrated composite hemostat according to Claim 1, wherein the oxidation degree of the oxidized regenerated cellulose or the alkali metal salt-neutralized product thereof is 13 to 24%.

11. The integrated composite hemostat according to Claim 10, wherein the oxidized regenerated cellulose or the alkali metal salt-neutralized product thereof having the oxidation degree of 18 to 24% is arranged on the side of contacting bleeding site, and the oxidized regenerated cellulose or the alkali metal salt-neutralized product thereof having the oxidation degree of 13 to 17% is arranged on the opposite side.

12. A method for preparing the integrated composite hemostat in the form of nonwoven fabric according to any one of Claims 1-11, comprising: (1) overlapping and needle punching (i) at least one web of a first polymer selected from the group consisting of a biodegradable polymer, oxidized regenerated cellulose and an alkali metal salt-neutralized product thereof and (ii) at least one web of a second polymer selected from the group consisting of oxidized regenerated cellulose and an alkali metal salt-neutralized product thereof; and (2) compressing the resulting product of (1), wherein the polymer webs of (i) and (ii) have different hemostatic effect or antiadhesive effect each other.

Description